Two forms of influenza virus nucleoprotein in infected cells and virions
Identifieur interne : 002712 ( Main/Exploration ); précédent : 002711; suivant : 002713Two forms of influenza virus nucleoprotein in infected cells and virions
Auteurs : O. P. Zhirnov [Russie] ; A. G. Bukrinskaya [Russie]Source :
- Virology [ 0042-6822 ] ; 1981.
English descriptors
- Teeft :
Abstract
Abstract: Two forms of influenza virus major nucleocapsid protein with MW 56,000 (NP56) and 53,000 (NP53) were revealed in infected cells and in the virions. NP53 was a secondary product of NP56 and accumulated in infected cells late in infection. Peptide mapping demonstrated that NP6 is a cleaved form of NP56. NP53 was found in the cells infected with different influenza A viruses, WSN (HON1), PR8 (HONI), FM1 (HlNl), FW/50 (HlN1), USSR 90 77 (HIND, Singapore (H2N2), England (H2N2), and Hong Kong (H3N2). NP56 å NP53 modification was a host-dependent event being readily expressed in chicken fibroblasts and porcine kidney embryo cells, to a lesser degree in MDCK cells, and greatly reduced in HeLa cells. The virions possessed NP53 as a minor component suggesting that RNPs containing NP56 but not NP53 are preferentially involved in budding process.
Url:
DOI: 10.1016/0042-6822(81)90482-7
Affiliations:
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